Now, Tomei has opened up about some plans for her character that never came to fruition in the Marvel Cinematic Universe, including the fact that the team had been “talking about” May having an LGBTQ+ relationship, until they decided, instead, that she should have a relationship with Tony Stark’s (Robert Downey, Jr.) chauffeur and confidante, Happy Hogan (Jon Favreau).
“At one point, before the idea of Happy showed up, there was a moment where I felt like, ‘Maybe she should just be with a woman.’ Because Ben is gone and who should she be with, and we were kind of talking about it.”
“I actually really wanted Amy Pascal from Sony to be my girlfriend. I was like, ‘No one even has to know Amy. I’ll just be in a scene and you’ll be over there and I’ll just be like, Hey,’ and it’ll just be a subtle thing.”
At this time, it seems that Tomei’s time in the MCU has come to an end, but now that the Marvel Multiverse has been broken wide open, never say never to a future appearance.
Joining Spider-Man: Homecoming (2017) and Spider-Man: Far From Home (2019), the official description of Spider-Man: No Way Home reads:
For the first time in the cinematic history of Spider-Man, our friendly neighborhood hero is unmasked and no longer able to separate his normal life from the high-stakes of being a Super Hero. When he asks for help from Doctor Strange the stakes become even more dangerous, forcing him to discover what it truly means to be Spider-Man.
Tom Holland (Peter Parker/Spider-Man) and Zendaya (MJ) are joined by Benedict Cumberbatch (Doctor Stephen Strange), Jon Favreau (Happy Hogan), Marisa Tomei (Aunt May), Jacob Batalon (Ned Leeds), and Alfred Molina (Doctor Octopus) in the film.